UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO
INSTITUTO NACIONAL DE PEDIATRÍA
Bone marrow failure and cancer predisposition laboratory
Institute for Biomedical Research, UNAM. The Unit for Genetic Nutrition, INP.
What do we study?
In this laboratory we study how DNA damage and genomic architecture determine cell fate.
We study the inherited bone marrow failure syndromes, childhood onset myelodisplastic syndrome (MDS) and childhood acute myeloid leukemia (AML).
The inherited bone marrow failure syndromes are rare diseases that present aplastic anemia and predisposition to MDS and AML.
Some inherited bone marrow failure syndromes are:
- Fanconi anemia
- Dyskeratosis congenita
- Blackfan Diamond anemia
- Shwachman-Diamond syndrome
The origins of inherited bone marrow failure syndromes include:
- DNA repair deficiency
- Telomere maintenance deficiency (telomeropathies)
- Ribogenesis deficiency (ribosomopathies)
- Born in Cuautla, Morelos, Mexico
- Bachelor, Master and PhD at UNAM, Mexico
- Specialty in Citogenetics at INP.
- Posdoctoral fellowship at Dana-Farber Cancer Institute, Harvard Medical School.
- Member of the Mexican Board of Genetics.
- Member of the Mexican Researchers System (SNI).
- Associate Researcher at Institute for Biomedical Research, UNAM
Cecilia Ayala Zambrano
PhD student. She studies epigenetic mechanisms involved in DNA repair
Pablo Siliceo Portugal
Bachelor Student. He studies the mechanisms involved in apoptosis vs survival cell fate decision in Fanconi anemia
Paula Leal Anaya Valenzuela
Specialty in Medical Genetics. She is developing the cohort of the mexican patients with inherited bone marrow failure syndromes.
Techniques and technologies that we use
- Classic and molecular cytogenetics
- DNA damage and repair assays
- Single cell resolution technologies
- Mathematical modelling